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Is Mitochondrial Dysfunction the Missing Link in Your Autoimmune Fatigue?

Is Mitochondrial Dysfunction the Missing Link in Your Autoimmune Fatigue?

Sunday, August 17, 2025

By Dr. Marie Nowlan, ND

Is Mitochondrial Dysfunction the Missing Link in Your Autoimmune Fatigue?

Is Mitochondrial Dysfunction the Missing Link in Your Autoimmune Fatigue?

If you live with an autoimmune condition, you probably know exactly what I mean when I talk about bone-deep fatigue—that “battery drained to zero” feeling that even a good night’s sleep can’t fix.

While there are many reasons fatigue can happen in autoimmunity, research is pointing to one often-overlooked piece of the puzzle: mitochondrial health.

How Mitochondria Work

Think of your mitochondria as the tiny power plants inside your cells. Their job is to take nutrients from your food and turn them into ATP—the energy currency your body uses for everything from thinking clearly, to moving your muscles, to repairing tissues.

When mitochondria are working well, you feel more energized, resilient, and able to bounce back from daily stressors.

Why They Struggle in Chronic Inflammation

In autoimmune disease, your immune system is in a heightened state of alert. This chronic inflammation can damage mitochondria in several ways:

  • Oxidative stress — inflammation creates an excess of reactive oxygen species (ROS) that damage mitochondrial structures.
  • Nutrient depletion — chronic illness can increase your need for certain vitamins, minerals, and amino acids that mitochondria rely on.
  • Immune signaling interference — inflammatory messengers can directly slow mitochondrial energy production.

Over time, this can lead to mitochondrial dysfunction, less ATP (energy), and that relentless fatigue so many people with autoimmunity face.

Simple Steps to Start Supporting Your Mitochondria Now

You don’t need to overhaul your life overnight to start helping your mitochondria recover. Small, consistent steps can make a real difference:

  1. Nourish with whole foods — prioritize colorful vegetables, fruits, omega-3 rich foods, nuts, seeds, and lean proteins to supply essential mitochondrial nutrients.
  2. Move (gently) every day — regular, moderate movement helps your body make new, healthier mitochondria without overtaxing your system.
  3. Manage inflammation triggers — by identifying and addressing the things that fuel inflammation—whether they’re environmental exposures, certain foods, lifestyle habits, or ongoing stress—you can lighten your body’s overall inflammatory load and, in turn, ease symptoms.
  4. Prioritize restorative sleep — mitochondria repair themselves while you sleep, so quality rest is essential.

These are starting points, but the full picture involves deeper layers of support, from targeted nutrients to strategic lifestyle shifts.

Ready to Learn More?

If you’re ready to explore mitochondrial health in more depth—including the latest research, personalized strategies, and how this fits into the bigger picture of autoimmune recovery—join me for my upcoming webinar:

“Why You’re Still Exhausted: Overlooked Causes of Autoimmunity”
⏰ Date & Time: Tuesday, August 19, 2025 @ 6:30–7:30 pm
🖥️ Free online event

👉 Register here

Together, we’ll go beyond autoimmunity and give you the tools to start restoring your energy from the inside out.

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